December Chemistry News

TCI Chemistry News December 2020



TCI offers an extensive catalog of 30,000 high quality organic reagents suitable for benchtop-to-bulk chemistry. This issue covers our chemistry expertise in organocatalyst for the prompt oxidation of alcohols, silanol salt for deprotection and cross-coupling reactions, chiral auxiliaries and optical resolving agents and stable phosphonium ylide.
organocatalyst for the orompt oxidation of alcohols

Organocatalyst for the Prompt Oxidation of Alcohols

2-Iodo-N-isopropyl-5-methoxybenzamide [I1117] is one of the iodobenzoic acid derivatives used as a catalyst in the oxidation of alcohols. Alcohols are rapidly oxidized in the presence of catalytic amount of I1117, potassium peroxymonosulfate as a cooxidant and tetrabutylammonium hydrogen sulfate as an additive. Secondary and primary alcohols are oxidized to ketones and carboxylic acids, respectively. Not only can I1117 be used as a catalyst in the conversion of tetrahydrofuran-2-methanol derivatives into γ-butyrolactone derivatives but it can also be recovered by purification after the reaction.
Read More
Silanol Salt for Deprotection Reactions and Cross-coupling Reactions

Silanol Salt for Deprotection and Cross-coupling Reactions

Potassium trimethylsiloxide [P2356] is used not only in the dealkylation of esters but also as a base in Suzuki-Miyaura cross-couplings, in the disconnection of carbon-silicon bond and hydrolysis of nitriles. It is believed that the dealkylation of esters using P2356 mainly proceeds through a nucleophilic attack of the silanolate anion and can be performed under milder conditions when compared to other reagents with the same reaction mechanism. In the Suzuki-Miyaura cross-coupling, the reaction can proceed rapidly under anhydrous conditions.
Read More
Chiral Auxiliaries and Optical Resolving Agents

Chiral Auxiliaries and Optical Resolving Agents

Most bioactive substances are optically active. For instance, if a substance is synthesized as a racemic compound, its enantiomer may show no activity or even undesired bioactivity. Thus, methods to synthesize enantiopure compounds have been developed. When synthesizing enantiopure compounds, the methods are roughly divided into three methods: chiral pool method, asymmetric synthesis and optical resolution. TCI offers many chiral auxiliaries for asymmetric synthesis, and chiral resolving reagents as well.

Read More
Stable Phosphonium Ylide

Stable Phosphonium Ylide

(Triphenylphosphoranylidene)acetonitrile [T1958] is a stable phosphonium ylide, which reacts as a Wittig reagent with a variety of carbonyl compounds to yield α,β-unsaturated nitriles. T1958 can also react with carboxylic acids, in the presence of EDCI and DMAP, to form cyanoketophosphoranes. Ozonolysis of cyanoketophosphoranes, and subsequent addition of nucleophiles such as amines or alcohols, results in α-keto amides, α-keto esters, etc. 

Read More

Follow Us on Social Media


How to Order TCI Products

To order, please contact your local distributor found below.

Countries/ Regions:

South Korea
Other Asia Pacific / Regions

» TCI eNewsletter Back Issues

* The prices displayed in the landing website are USD based catalog prices.  TCI has specific website and local currency based price list for customers in South Korea, Singapore, and Australia.  For customers in other Asia Pacific countries / regions, please visit our Asia Pacific Website and contact our local distributors for the end user's cost. (The USD prices that are shown in Asia Pacific websites are TCI's catalog prices.)
Please visit each country/region's website from the following links and confirm the prices.

Tokyo Chemical Industry Co., Ltd. (TCI)
Global Business Department
Customer Support and Technical service


Connect with TCI

Facebook_S Twitter_S Linkedin_S Instagram_S TCI_S

Copyright © 2020
Tokyo Chemical Industry Co., Ltd.
4-10-2 Nihonbashi-honcho, Chuo-ku,Tokyo 103-0023 Japan

Privacy Policy