October Life Science News

TCI Life Science News  October 2020



At TCI, we support discovery in life sciences through our knowledge and expertise in organic small molecules. In this issue we focus on our fluorescent organosilica, quaternary ammonium salts, DNA Ligase Inhibitor: SCR7 Pyrazine and professor Ujike’s article on SARS-CoV-2 in latest TCIMAIL. We also have thousands of other useful compounds available only at TCI for your research and development.
Organosilica FITC 100nm

Organosilica FITC 100nm

Various types of fluorescent dyes have been used to detect biomolecules. However they are not always suitable for observing them depending on their detection methods. Although fluorescent silica particles with enhanced fluorescence intensity have been used in the past, they are often large in diameter and difficult to control the size of the produced particles. TCI offers Organosilica FITC 100 nm [O0561] which has a small and uniform particle size distribution and higher fluorescence intensity than conventional FITC.
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Quaternary Ammonium Salts for Life Science

Quaternary Ammonium Salts for Life Science

Quaternary ammonium is an organic compound in which the ammonia molecule is tetrasubstituted with carbon and has a cationic state. A lot of quaternary ammonium salts have been synthesized and the various applications have been reported so far. For example, in organic chemistry, cetyltrimethylammonium bromide (CTAB) [H0081] as a DNA extraction reagent, benzethonium chloride [B0044] as a cationic surfactant, benzalkonium chloride [B0414] as a cationic surfactant, and cetylpyridinium chloride (CPC) [H0078] as a cationic surfactant have been reported.
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DNA Ligase Inhibitor: SCR7 Pyrazine

DNA Ligase Inhibitor: SCR7 Pyrazine

Initially, it was believed that SCR7 could block non-homologous end joining (NHEJ) mediated DNA repair by inhibiting DNA ligase IV, resulting in the increase of the genome editing efficiency of CRISPR-Cas9. However, researchers found later that the major product which was formed from the initial synthetic method was SCR7 pyrazine [C3577], not SCR7, and SCR7 itself could not inhibit DNA ligase IV. After that, it has been reported that SCR7 cyclizes automatically due to its instability, and is autoxidized to give SCR7 pyrazine. The SCR7 pyrazine inhibits NHEJ in vitro although its selectivity to DNA ligase IV is not so high.
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TCI Chemistry Research: TCIMAIL 184

Released in August, TCI's latest issue features Assoc. Prof. Makoto Ujike's article on infection called "Current Status of Drug development against the Novel Coronavirus, SARS-CoV-2”. We also feature articles on:

Be sure to check out our previous issues of TCIMAIL that contain various scientific articles from researchers around the world!

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