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TCI Chemistry News  September 2021

 
 

 

 
TCI offers an extensive catalog of 30,000 high-quality organic reagents suitable for benchtop-to-bulk chemistry. This issue covers our chemistry expertise and introduces a chiral ligand for the synthesis of optically active aziridines, an electrophilic sulfur-introducing reagent for fused thiophene derivative synthesis, peptide coupling using a Mukaiyama condensation reagentolefin metathesis using UltraCat and our research publication TCIMAIL volume 187.
Chiral Ligand for the Synthesis of Optically Active Aziridines

Chiral Ligand for the Synthesis of Optically Active Aziridines

A reaction using (-)-4-tert-butyl-2,6-bis[(4S,5S)-4,5-tetramethylene-1-(2,4,6-trimethylbenzenesulfonyl)imidazolin-2-yl]phenol [B6146] as a chiral ligand enables the synthesis of optically-active aziridines from 2H-azirines. The addition of 2H-azirine and diphenyl phosphite to the reaction mixture of B6146, MS 4A, and diethylzinc produces the optically-active aziridine. The aziridines can be converted to chiral amines and oxazolines without loss of enantiopurity.
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Electrophilic Sulfur Introducing Reagent for Fused Thiophene Derivative Synthesis

Electrophilic Sulfur Introducing Reagent for Fused Thiophene Derivative Synthesis

Bis(phenylsulfonyl) sulfide [B3288] can form a variety of thiophene rings or rigid sulfide bonds by the reaction with nucleophiles such as aryl lithium under mild conditions.  B3288 is a synthetic equivalent of sulfur dichloride (SCl2), which is highly toxic and difficult to handle. Benzenesulfinic acid, a byproduct of the reaction, can be easily removed by liquid separation and purification.
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Peptide Coupling using Mukaiyama Condensation Reagent

TCI Practical Example: Peptide Coupling using Mukaiyama Condensation Reagent

TCI is proud to introduce an improvement of the amidation step using 2-chloro-1-methylpyridinium iodide [C0903], the Mukaiyama condensation reagent. 2-Chloro-1-methylpyridinium iodide is known to cause less racemization.
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Olefin Metathesis Using UltraCat

TCI Practical Example: Olefin Metathesis Using UltraCat

TCI is proud to introduces the ring-closing metathesis of diethyl diallylmalonate using UltraCat [U0141] as a catalyst. The reaction report was performed by TCI's synthesis staff. You can see not only the reaction procedure but also the comment and analysis data from our staff.
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TCIMAIL 187

TCI Chemistry Research: TCIMAIL 187

Released in August 2021, TCI's latest issue features Prof. Tomohiro Asai’s article "Nucleic Acid Delivery System with DOP-DEDA, a Charge-Reversible Lipid Derivative", an article by Nippon Fine Chemical Co., Ltd. "Preparing Liposome Mixtures with Nippon Fine Chemical’s High-purity Phospholipids and Presome® Series", and Prof. Nagatoshi Nishiwaki’s chemistry chat. We also feature research on:

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