Electrophilic Sulfur Introducing Reagent for Fused Thiophene Derivative Synthesis
Bis(phenylsulfonyl) sulfide [B3288] can form a variety of thiophene rings or rigid sulfide bonds by the reaction with nucleophiles such as aryl lithium under mild conditions. B3288 is a synthetic equivalent of sulfur dichloride (SCl2), which is highly toxic and difficult to handle. Benzenesulfinic acid, a byproduct of the reaction, can be easily removed by liquid separation and purification.
TCI Practical Example: Peptide Coupling using Mukaiyama Condensation Reagent
TCI is proud to introduce an improvement of the amidation step using 2-chloro-1-methylpyridinium iodide [C0903], the Mukaiyama condensation reagent. 2-Chloro-1-methylpyridinium iodide is known to cause less racemization.
TCI Practical Example: Olefin Metathesis Using UltraCat
TCI is proud to introduces the ring-closing metathesis of diethyl diallylmalonate using UltraCat [U0141] as a catalyst. The reaction report was performed by TCI's synthesis staff. You can see not only the reaction procedure but also the comment and analysis data from our staff.