Hypervalent Iodine Reagent for the Introduction of Indoles via C-H Activation of Arenes
N-H-indole BX [I1126] is a stable hypervalent iodine compound used for the introduction of an indole ring via C-H bond activation of (hetero)arenes. In the presence of a rhodium or ruthenium catalyst, N-H-indole BX can be used to regioselectively introduce an indole ring into arenes with directing groups. In this reaction, the indole ring can be introduced in a manner that is hard to achieve by conventional methods due to the natural nucleophilicity of indole ring. Furthermore, the indole ring can be introduced at the 6- and 8-position of pyridinones and quinoline-N-oxides, respectively.
TCI Practical Example: Buchwald-Hartwig Amination of Aryl Chlorides using a Palladium Catalyst and XPhos Ligand
We are proud to present the Buchwald-Hartwig cross-coupling of aryl chloride utilizing Pd(dba)2 [B1374] catalyst, and XPhos [D5038] ligand. The reaction report is performed by TCI synthesis experts. You can see not only the reaction procedure but also the useful comment and analysis data from our experts.
The aldol reaction is an addition reaction of a ketone or an aldehyde with a hydrogen atom at the α-position and another ketone or aldehyde to give a β-hydroxy carbonyl compound. In this reaction, an enol or an enolate, generated by the treatment of the carbonyl compound with an acid or a base, nucleophilically adds to the other carbonyl compound to give the corresponding target compound.