Sulfonium Salt Utilized both in Mesitylation and in Trifluoromethylation
Dimesityl(trifluoromethyl)sulfonium trifluoromethanesulfonate [D5889] is a sulfonium salt also known as Mes-Umemoto reagent or Yagupolskii-Umemoto reagent. D5889 was first reported as a mesitylating reagent in cross-coupling, but later D5889 was found to be utilized in trifluoromethylation of (hetero)aryl bromides and alkyl bromides. The trifluoromethyl group is introduced by the photoredox reactions in any substrates and the reaction proceeds in complicated molecules like drugs in good or high yields. So D5889 is also useful to introduce the trifluoromethyl group at the late stage.
TCI Practical Example: Reductive C-N Cross-Coupling Reaction using an Organophosphorus Catalyst
TCI shows the synthesis of a secondary arylamine by the reductive C-N cross-coupling reaction of a nitroarene and an arylboronic acid using anti-1,2,2,3,4,4-hexamethylphosphetane 1-oxide [H1766] as an organocatalyst. The reaction report is actually performed by TCI's synthesis staff. You can see not only the reaction procedure but also the comment and analysis data from our staff.
TCI Practical Example: Cross Metathesis Using UltraNitroCat
TCI introduces the olefin cross metathesis between acrylonitrile and ethyl 10-undecenoate using UltraNitroCat [U0116] as a ruthenium catalyst. The reaction report says that the reaction conversion rate of 11-cyano-10-undecenoic acid ethyl ester and 10-eicosenedioic acid diethyl ester are 69.3% and 6.3%, respectively. The selectivity ratio is 92 : 8.
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