TCI offers a vast selection of antiviral agents for research and experimental use. Some of the trends in COVID-19 pharmaceutical development include the search for viral proteases 3CLpro or PLpro inhibitors, viral protein expression inhibitors, viral entry to host cells inhibitors, as well as inhibitors of viral replication. See TCI's antiviral product line with reported mechanisms, product numbers, and target virus types.
Chlorination of (Hetero)arene Derivatives with DMSO Catalyst
In a recent study of DMSO-catalysed late-stage chlorination of (hetero)arenes, Jiao’s group reported chlorination of (hetero)arenes with N-chlorosuccinimide (NCS) [C0291] and a catalytic amount of DMSO [D0798]. The reaction is applied to a wide variety of (hetero)arenes such as indoles, pyridines, and thiophenes with high yield and high regioselectivity. The chlorination can be carried out under neutral and mild conditions, so it is expected to be applied to drug discovery and development in late-stage synthesis.
Sodium tris(1,1,1,3,3,3-hexafluoroisopropoxy)borohydride [S0810] is a selective reducing agent developed by Toshima et al. Aldehydes are selectively reduced in the presence of ketones and other reducible functional groups using S0810 to afford the corresponding primary alcohols in high yields. This is a useful method for reduction of aldehydes because it does not require the addition of other reagents and the reaction is very simple and convenient.
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