July Chemistry News

TCI Chemistry News August 2020



TCI offers an extensive catalog of 30,000 high quality organic chemicals suitable for benchtop-to-bulk chemistry. This issue covers our chemistry expertise in diene derivative with high reactivity for Diels-Alder reactionelectron-deficient cyclopentadienyl ligand precursor and its rhodium complexair-stable tri-tert-butylphosphine equivalentSimmons-Smith cyclopropanation reaction and more.

diene derivative with high reactivity for Diels-Alder reaction

Diene Derivative with High Reactivity for Diels-Alder Reaction

Rawal’s diene [B5597] is a building block used in (hetero) Diels-Alder reactions with research showing reactivity of B5597 being 1,000 times higher than the popular Danishefsky-Kitahara diene due to a higher HOMO level of B5597. Additionally, silyl enol ethers can be hydrolyzed under acidic conditions to afford α,β-unsaturated ketones. Because this method is very efficient, we are seeing an increase in B5597’s use in the total syntheses of natural products.
Read More
Electron-deficient Cyclopentadienyl Ligand Precursor and its Rhodium Complex

Electron-deficient Cyclopentadienyl Ligand Precursor and its Rhodium Complex

D5585 is a precursor of the electron-deficient cyclopentadienyl ligand (CpE) and utilized in the formation of metal complexes with just a few steps. B6169, a rhodium complex, is prepared from D5585 and is a powerful precatalyst for C-H bond activation such as oxidative annulation of anilides with alkynes, and oxidative olefination of anilides with alkenes.
Read More
air-stable tri-tert-butylphosphine equivalent

Air-Stable Tri-tert-butylphosphine Equivalent

When using tri-tert-butylphosphine, researchers tend to find unusual and unique reactivity compared to other phosphine ligands due to it being electron rich and its steric bulk. Unfortunately, tri-tert-butylphosphine is incredibly air-sensitive making it difficult to handle. To increase the ease of use, we offer the equivalent tri-tert-butylphosphonium tetrafluoroborate [T2584] that is stable enough to be stored in air for a long period of time. Also, when using tri-tert-butylphosphine in situ as generated from T2584, various other cross-coupling reactions have been facilitated.
Read More
Simmons-Smith Cyclopropanation Reaction

Simmons-Smith Cyclopropanation Reaction

The Simmons-Smith cyclopropanation reaction is a classic method used to construct a cyclopropane moiety from a parent alkene. The reaction is typically conducted using diiodomethane [D0610] in combination with metallic zinc and copper (Zn/Cu). Zn/Cu can be replaced with diethylzinc [D3214], which is known as the Furukawa modification. The Simmons-Smith reaction has considerable advantages over other cyclopropanation methods as it does not require the use of the highly hazardous diazomethane. In addition, this reaction has a wide functional group tolerance including with alkynes, carbonyls, alcohols, ethers, and also can proceed stereospecifically.
Read More

Follow Us On Social Media


How to Order TCI Products

To order, please contact your local distributor found below.

Countries/ Regions:

South Korea
Other Asia Pacific / Regions

» TCI eNewsletter Back Issues

* The prices displayed in the landing website are USD based catalog prices.  TCI has specific website and local currency based price list for customers in South Korea, Singapore, and Australia.  For customers in other Asia Pacific countries / regions, please visit our Asia Pacific Website and contact our local distributors for the end user's cost. (The USD prices that are shown in Asia Pacific websites are TCI's catalog prices.)
Please visit each country/region's website from the following links and confirm the prices. 

Tokyo Chemical Industry Co., Ltd. (TCI)
Global Business Department
Customer Support and Technical service

» globalbusiness@TCIchemicals.com
» https://www.TCIchemicals.com

Connect with TCI

Facebook_S Twitter_S Linkedin_S Instagram_S TCI_S

Copyright © 2020
Tokyo Chemical Industry Co., Ltd.
4-10-2 Nihonbashi-honcho, Chuo-ku,Tokyo 103-0023 Japan
E-mail: TCIeNewsletter@TCIchemicals.com

Privacy Policy