February Life Science News
 

TCI Life Science News  February 2021

 
 

 

 
At TCI, we support discovery in life sciences through our knowledge and expertise in organic small molecules. In this issue we focus on our sulfated hyaluronic acids, carbohydrate-binding proteins, a phospholipid for lipid nanoparticles, and the latest issue of TCIMAIL. We also have thousands of other useful compounds available only at TCI for your research and development.
Sulfated Hyaluronic Acids

Sulfated Hyaluronic Acids

Sulfated hyaluronic acid is known to stabilize growth factors, such as FGF1 and FGF2. As a result it is expected to be used as a substitute for sulfated polysaccharides in the context of regenerative medicine as well as in several other fields where sulfated polysaccharides may be needed. TCI offers sulfated hyaluronic acid with various sulfation degree [H1739, H1740] that can be modified by changing the synthetic reaction.
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Carbohydrate-binding Proteins -Anti-Glyco Antibodies and Lectins-

Carbohydrate-binding Proteins -Anti-Glyco Antibodies and Lectins-

Carbohydrate chains are called the third life chain following the protein and the nucleic acid and are one of the most important topics in post genome research. Most carbohydrate chains attach to lipids or proteins and occur in the form of glycoproteins or glycolipids. Carbohydrate chains are known to be expressed in brain, nerve, cancer, and endothelial cells. Some carbohydrate chains are known to be related to diseases (e.g., cancer, Alzheimer's disease, Guillain-Barré syndrome, Lysosome syndrome such as Fabry disease, gangliosidosis) as well as differentiation and development (iPS/ES cells). TCI offers useful anti-carbohydrate chain antibodies and lectins for your research and development.
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Phospholipid for Charge-reversible Lipid Nanoparticles to Deliver siRNA

Phospholipid for Charge-reversible
Lipid Nanoparticles to Deliver siRNA

RNA interference induced intracellularly by small interfering RNAs (siRNAs) consisting of 21 to 23 nucleobase pairs is considered to be a promising candidate for cancer therapy, as it inhibits gene expression by promoting the degradation of target messenger RNAs (mRNAs). DOP-DEDA [D5882] is a charge-reversible phospholipid suitable for preparing lipid nanoparticles (liposomes) for siRNA delivery into cells. While conventional lipid nanoparticles for siRNA delivery are aggregated under physiological conditions because of loss of ionization, or require PEGylation, it has been reported that siRNA-encapsulated lipid nanoparticles composed of DOP-DEDA are always ionized and thus can be taken up into cancer cells.
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TCI Chemistry Research: TCIMAIL 185

TCI Chemistry Research: TCIMAIL 185

Released in November 2020, TCI's latest issue features Assoc. Prof. Michael Schnürch's article on cross-coupling called "Sequential Triple Cross-Coupling towards Synthesis of 2,4,5-Trisarylthiazoles”. We also feature research on:

Be sure to check out our previous issues of TCIMAIL that contain various scientific articles from researchers around the world!
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