Sulfated hyaluronic acid is known to stabilize growth factors, such as FGF1 and FGF2. As a result it is expected to be used as a substitute for sulfated polysaccharides in the context of regenerative medicine as well as in several other fields where sulfated polysaccharides may be needed. TCI offers sulfated hyaluronic acid with various sulfation degree [H1739, H1740] that can be modified by changing the synthetic reaction.
Carbohydrate-binding Proteins -Anti-Glyco Antibodies and Lectins-
Carbohydrate chains are called the third life chain following the protein and the nucleic acid and are one of the most important topics in post genome research. Most carbohydrate chains attach to lipids or proteins and occur in the form of glycoproteins or glycolipids. Carbohydrate chains are known to be expressed in brain, nerve, cancer, and endothelial cells. Some carbohydrate chains are known to be related to diseases (e.g., cancer, Alzheimer's disease, Guillain-Barré syndrome, Lysosome syndrome such as Fabry disease, gangliosidosis) as well as differentiation and development (iPS/ES cells). TCI offers useful anti-carbohydrate chain antibodies and lectins for your research and development.
Phospholipid for Charge-reversible Lipid Nanoparticles to Deliver siRNA
RNA interference induced intracellularly by small interfering RNAs (siRNAs) consisting of 21 to 23 nucleobase pairs is considered to be a promising candidate for cancer therapy, as it inhibits gene expression by promoting the degradation of target messenger RNAs (mRNAs). DOP-DEDA [D5882] is a charge-reversible phospholipid suitable for preparing lipid nanoparticles (liposomes) for siRNA delivery into cells. While conventional lipid nanoparticles for siRNA delivery are aggregated under physiological conditions because of loss of ionization, or require PEGylation, it has been reported that siRNA-encapsulated lipid nanoparticles composed of DOP-DEDA are always ionized and thus can be taken up into cancer cells.
* The prices displayed in the landing website are USD based catalog prices. TCI has specific website and local currency based price list for customers in South Korea, Singapore, and Australia. For customers in other Asia Pacific countries / regions, please visit our Asia Pacific Website and contact our local distributors for the end user's cost. (The USD prices that are shown in Asia Pacific websites are TCI's catalog prices.) Please visit each country/region's website from the following links and confirm the prices. https://www.TCIchemicals.com