Fluorescence imaging is an important research method in the field of life science. TCI offers many fluorescence probes which can be used for various experiments such as fluorescence staining, flow cytometry, florescent western blotting, and FLISA. You can see application data and some fluorescence micrographs.
BAPTA [B3895] and BAPTA-Na4 [T2844] are highly selective chelators for Ca2+ over Mg2+. Their selectivity for Ca2+ is higher than the selectivity of EGTA, and the binding does not depend on pH. Their chelation reactions are more rapid than that of EGTA, thus, it has been reported that the distances between Ca2+ channels and Ca2+ sensors in neurons can be evaluated by analyzing the transmitter release inhibition by different chelators. While both BAPTA and BAPTA-Na4 are membrane-impermeable, BAPTA-AM [T2845], a BAPTA ester, is membrane-permeable and can chelate with Ca2+ in cells after the hydrolysis by intracellular esterases.
Rolipram [R0110] is a selective inhibitor of phosphodiesterases 4 (PDE4s). PDE4s are responsible for hydrolysis of the cyclic nucleotides cAMP and cGMP to 5'-AMP and 5'-GMP, respectively, particularly in nerve and immune cells. The inhibition of PDE4s by rolipram induces the elevation of intracellular cAMP concentration. Consequences rolipram-induced elevation of cAMP suppress expression of proinflammatory cytokines and other mediators of inflammation. (R)-(−)-Rolipram [R0182] is the active enantiomer of rolipram, and has been reported that (R)-(−)-rolipram is approximately 3 times more potent than (S)-(+)-rolipram [R0183] against PDE4s.
* The prices displayed in the landing website are USD based catalog prices. TCI has specific website and local currency based price list for customers in South Korea, Singapore, and Australia. For customers in other Asia Pacific countries / regions, please visit our Asia Pacific Website and contact our local distributors for the end user's cost. (The USD prices that are shown in Asia Pacific websites are TCI's catalog prices.) Please visit each country/region's website from the following links and confirm the prices. https://www.TCIchemicals.com