Diene Derivative with High Reactivity for Diels-Alder Reaction
Rawal’s diene [B5597]is a building block used in (hetero) Diels-Alder reactions with research showing reactivity of B5597 being 1,000 times higher than the popular Danishefsky-Kitahara diene due to a higher HOMO level of B5597. Additionally, silyl enol ethers can be hydrolyzed under acidic conditions to afford α,β-unsaturated ketones. Because this method is very efficient, we are seeing an increase in B5597’s use in the total syntheses of natural products.
Electron-deficient Cyclopentadienyl Ligand Precursor and its Rhodium Complex
D5585 is a precursor of the electron-deficient cyclopentadienyl ligand (CpE) and utilized in the formation of metal complexes with just a few steps. B6169, a rhodium complex, is prepared from D5585 and is a powerful precatalyst for C-H bond activation such as oxidative annulation of anilides with alkynes, and oxidative olefination of anilides with alkenes.
When using tri-tert-butylphosphine, researchers tend to find unusual and unique reactivity compared to other phosphine ligands due to it being electron rich and its steric bulk. Unfortunately, tri-tert-butylphosphine is incredibly air-sensitive making it difficult to handle. To increase the ease of use, we offer the equivalent tri-tert-butylphosphonium tetrafluoroborate [T2584] that is stable enough to be stored in air for a long period of time. Also, when using tri-tert-butylphosphine in situ as generated from T2584, various other cross-coupling reactions have been facilitated.
The Simmons-Smith cyclopropanation reaction is a classic method used to construct a cyclopropane moiety from a parent alkene. The reaction is typically conducted using diiodomethane [D0610] in combination with metallic zinc and copper (Zn/Cu). Zn/Cu can be replaced with diethylzinc [D3214], which is known as the Furukawa modification. The Simmons-Smith reaction has considerable advantages over other cyclopropanation methods as it does not require the use of the highly hazardous diazomethane. In addition, this reaction has a wide functional group tolerance including with alkynes, carbonyls, alcohols, ethers, and also can proceed stereospecifically.
* The prices displayed in the landing website are USD based catalog prices. TCI has specific website and local currency based price list for customers in South Korea, Singapore, and Australia. For customers in other Asia Pacific countries / regions, please visit our Asia Pacific Website and contact our local distributors for the end user's cost. (The USD prices that are shown in Asia Pacific websites are TCI's catalog prices.) Please visit each country/region's website from the following links and confirm the prices. https://www.TCIchemicals.com