Building Blocks for Synthesis of Proteolysis Targeting Compounds
In recent years, research in medicinal chemistry has increased the investigation in the use of the ubiquitin-proteasome system (UPS) to combat diseases. As a result, a variety of chimera compounds have been synthesized consisting of a tag that can bind to ubiquitin ligase, a linker and another ligand that can bind to disease related proteins. This enables us to bring the disease related protein in proximity to an activated UPS to eliminate the protein. Measuring the activity of these compounds has shown that the length of the linker is an important factor in triggering ubiquitination. TCI now offers hetero-bifunctional linkers with a variety of lengths.
2-trans-Dodecanoyl-CoA [D5661] acts on enoyl-ACP reductase (InhA) as one of 2-trans-enoyl-ACP, a substrate for InhA in the synthesis pathway of fatty acids, which constitute the cell wall of Mycobacterium tuberculosis. Therefore, it is reported that InhA inhibiiton assay by measuring InhA's reducing activity of 2-trans-Dodecanoyl-CoA can be applied for the screening of anti-tuberculosis agent candidates.
The statins inhibit the action of HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase that catalyzes the rate-limiting step in cholesterol biosynthesis, resulting in the reduction of low-density-lipoprotein (LDL) and total cholesterol levels. Especially in statins, atorvastatin [A2476] is a most potent inhibitor due to its a long half-life and metabolites which also play a role as an HMG-CoA reductase inhibitor. Lovastatin [L0214], mevastatin [M2275] and simvastatin [S0509] are pro-drug ingredients that are activated by in vivo hydrolysis of the lactone ring. Many statins are metabolized by cytochrome P450 3A4 (CYP3A4) while fluvastatin [F0820] is metabolized by CYP2C9.
Chemiluminescence is the phenomenon of energy released as light when the excited state of molecules by oxidation returns to the ground state. Organic substances which exhibit chemiluminescene are Cypridina luciferin analog, firefly luciferin, oxalate, luminol and acridinium, etc. TCI also offers chemiluminescence enhancers for chemiluminescent enzyme immunoassays.
* The prices displayed in the landing website are USD based catalog prices. TCI has specific website and local currency based price list for customers in South Korea, Singapore, and Australia. For customers in other Asia Pacific countries / regions, please visit our Asia Pacific Website and contact our local distributors for the end user's cost. (The USD prices that are shown in Asia Pacific websites are TCI's catalog prices.) Please visit each country/region's website from the following links and confirm the prices. https://www.TCIchemicals.com